Genetic factors could be behind the difference in the prevalence between the two populations and may influence the age of onset of the disease.
Objective: The aims of our study were to assess whether the distribution of 16 single Objective: The aims of our study were to assess whether the distribution of 16 single nucleotide polymorphisms SNPs with unequivocal effects on the development of T2DM contributes to the higher prevalence of T2DM among Roma and to evaluate the impact of genetic factors on the age of onset for T2DM in addition to conventional risk factors also in the Hungarian population.
Methods: A total of samples of T2DM individuals, samples from Hungarian general population and samples from segregated colonies of Roma were included in our study. Associations between GRSs and fasting glucose level and T2DM status were investigated in separate and combined study populations.
Our results also suggest that there is a considerable genetic predisposition for early onset of T2DM among them. Interventions targeting T2DM prevention should focus on harmful environmental exposures related to their unhealthy lifestyle and GRS can be used as a tool for stratifying and estimating the risk of earlier onset of T2DM in addition to conventional risk factors.