Insulin resistance ncbi. [Deletion 15q26 syndrome]

[Sarcopenia - 2021: Pathophysiology, diagnosis, therapy]

Abstract Study Objectives Many adolescents are exposed to sleep restriction on school nights. We assessed how different apportionment of restricted sleep continuous vs.

1. Introduction

Methods Adolescents, aged 15—19 years, were evaluated in a dormitory setting using a parallel-group design. Following two baseline nights of 9-hour time-in-bed TIBparticipants underwent either 5 nights of continuous 6.

After two recovery nights of 9-hour TIB, participants were sleep restricted for another three nights.

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Sleep was assessed using polysomnography PSG. Cognitive performance and mood were evaluated three times per day. Oral glucose tolerance tests OGTT were conducted on mornings after baseline sleep, recovery sleep, and the third day of each sleep restriction cycle.

Results The split sleep group had fewer vigilance lapses, better working memory and executive function, faster processing speed, lower level of subjective sleepiness, and more positive mood, even though PSG-verified total sleep time was less than the continuous sleep group.

However, vigilance in both sleep-restricted groups was inferior to adolescents insulin resistance ncbi a prior sample given 9-hour nocturnal TIB.

During both cycles of sleep restriction, blood glucose during the OGTT increased by a greater amount in the split sleep schedule compared with persons receiving 6.

a kezelés a számok az ujjak a lábakon közben cukorbetegség

Conclusions In adolescents, modest multinight sleep restriction had divergent negative effects on cognitive performance and glucose levels depending on how the restricted sleep was apportioned. They are best advised to obtain the recommended amount of nocturnal sleep.

  1. Súlya a cukorbetegség kezelésében
  2. [Insulin resistance and its effects in children and adolescents]

Trial registration Keywords: adolescents, cognition, continuous sleep, glucose tolerance, partial sleep deprivation, sleep restriction, split sleep, vigilance Statement of Significance Many adolescents do not get adequate sleep, but the outcomes of how that restricted sleep is apportioned have not been studied.

During a simulated school week with time-in-bed restricted to 6. However, they exhibited a greater increase in blood glucose during a glucose tolerance test.

MeSH terms

Under conditions of suboptimal sleep, effects on neurobehavioral outcomes and morning glucose levels diverge depending on how sleep is apportioned. Introduction Many adolescent students sleep less than the recommended duration of 8—10 hours [ 12 ] a night [ 34 ]. Even those who take compensatory naps may fall short of their daily sleep need for optimal cognitive performance, mood and physical health.

What is insulin resistance (and why does it occur)?

Existing sleep restriction studies have mainly examined adults and have evaluated cognition and metabolism separately with protocols that mostly manipulate only nocturnal sleep insulin resistance ncbi 5—8 ].

The handful of studies that examined split sleep kezelési módszerek a cukorbetegség in working-age adults found that such schedules yield comparable cognitive performance when compared to an equivalent amount of continuous sleep [ 12—15 ].

However, no insight has been provided about their metabolic impact, a significant gap given that short sleep is associated with increased risk of diabetes mellitus [ 1617 ].

Expert opinion suggests that optimal sleep duration for maintenance of neurobehavioral function and metabolic health may differ [ 18 ], but there is a dearth of supportive empirical data. The aim of the present study was to determine whether neurobehavioral function and glucose levels differ in sleep-restricted adolescents when sleep is either split primary night sleep opportunity with a daytime insulin resistance ncbi or taken in a single nocturnal sleep episode.

The two cycles of sleep restriction provided an opportunity to evaluate the degree of recovery following the intervening recovery sleep 9-hour TIB as well as the added alterations in neurobehavioral function [ 9 ], and the consistency of glucose tolerance measurements.

Publication types

Neurobehavioral function in these two groups was also compared to a insulin resistance ncbi historical control group that received an age-appropriate amount of sleep insulin resistance ncbi TIB every night over 2 weeks [ 19 ]. A total of adolescents were assessed for eligibility for this day parallel-group study. Two participants dropped out, and analyses were based on 58 participants Supplementary Figure S1.

Although the primary goal of the current work was to compare two sleep restriction schedules, the data generated were also appraised in light of the recommended sleep duration for adolescents 8—10 hours per night.

To this end, we compared the present findings to previously published data on students sleeping 9-hour TIB at night [ 19 ], recruited using the recruitment criteria used in the present study. Although the split and the continuous sleep groups did not differ in sleep behavior based on both self-report [ 24 ] and actigraphy Table 1some slight differences were found with the control group from our previous protocol 3 years ago.

If G-banded karyotyping fails to detect large chromosomal aberrations, array comparative genomic hybridization array CGH should be performed to screen for submicroscopic pathological copy number changes. The authors present a six-year-old girl whose symptoms arose from a 4. The syndrome is characterized by a resistance to the insulin-like growth factor 1 - in our case the increased level of the insulin-like growth factor 1 together with the persistent longitudinal growth failure was an important finding and differential diagnostic feature. A brief overview of the literature is provided.

Specifically, the control group seemed to sleep less on weekdays, but extended their sleep more on weekends. Overall, based on actigraphy data, the three groups spent about 6.

Associated Data

This was far less than the recommended sleep duration of 8—10 hours for adolescents [ 12 ]. Table 1.

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Characteristics of all manipulation and control groups Split sleep group.

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