Acta Medica Margit-László, F. Each experiment lasted 5 hours. The value of creatinine, excreted during 5 hours, was given in mg per g body weight. We determined also the ratio Na:K. The results for the animals with their infundibulum damaged are shown in Table I. In the animals with infundibular lesion, the concentration and excreted amount of the examined ions rose the increase in the excretion of potassium was insignificantwhile — in contrast to intact animals — urinary volume and creatinine excretion became considerably less.
Table II shows the results for the hypophysectomized rats and rats which received a subcutaneous injection of 5 mg of cortisone Adreson, Organon, Oss 12 hours prior to diabetes insipidus test results water load.
These were identical with those described in earlier communications [5, 6, 15]. The diuretic and saluretic actions of chlorothiazide became less pronounced in rats with reduced creatinine excretion that had been hypophysectomized several weeks earlier.
When, on the other hand, hypophysectomized animals were given cortisone, the diureticsaluretic effect of chlorothiazide was intensified and the excretion of creatinine more pronounced. Discussion The administration of chlorothiazide elicited different reactions in patients suffering from diabetes insipidus and those suffering from psychogenic polydipsia.
The discrepancy might seem surprising, a lack of ADH being responsible for both conditions.
Yet, while the production of ADH is inhibited by a disorder of the hypothalamo-neurohypophyseal system in diabetes insipidus, the brain centres are unimpaired in psychogenic polydipsia and it is the hypo-osmosis which prevents the mobilization of the hormone. Even the symptoms are practically the same in both syndromes and the.